Protein name:
Meiotic recombination protein REC8 homolog ;
Alternative:
Cohesin Rec8p ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51.
Function:
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
Subcellular Location:
Nucleus
Chromosome
In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.
Protein Attributes:
50:
MFYYPNVLQR | HTGCFATIWL | AATRGSRLVK | REYLRVNVVK | TCEEILNYVL |
100:
VRVQPPQPGL | PRPRFSLYLS | AQLQIGVIRV | YSQQCQYLVE | DIQHILERLH |
150:
RAQLQIRIDM | ETELPSLLLP | NHLAMMETLE | DAPDPFFGMM | SVDPRLPSPF |
200:
DIPQIRHLLE | AAIPERVEEI | PPEVPTEPRE | PERIPVTVLP | PEAITILEAE |
250:
PIRMLEIEGE | RELPEVSRRE | LDLLIAEEEE | AILLEIPRLP | PPAPAEVEGI |
300:
GEALGPEELR | LTGWEPGALL | MEVTPPEELR | LPAPPSPERR | PPVPPPPRRR |
350:
RRRRLLFWDK | ETQISPEKFQ | EQLQTRAHCW | ECPMVQPPER | TIRGPAELFR |
400:
TPTLSGWLPP | ELLGLWTHCA | QPPPKALRRE | LPEEAAAEEE | RRKIEVPSEI |
450:
EVPREALEPS | VPLMVSLEIS | LEAAEEEKSR | ISLIPPEERW | AWPEVEAPEA |
500:
PALPVVPELP | EVPMEMPLVL | PPELELLSLE | AVHRAVALEL | QANREPDFSS |
547:
LVSPLSPRRM | AARVFYLLLV | LSAQQILHVK | QEKPYGRLLI | QPGPRFH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Meiotic recombination protein REC8 homolog
ELISA Kit for Human Meiotic recombination protein REC8 homolog
ELISA Kit for Human Meiotic recombination protein REC8 homolog
CLIA Kit for Human Meiotic recombination protein REC8 homolog
CLIA Kit for Human Meiotic recombination protein REC8 homolog
CLIA Kit for Human Meiotic recombination protein REC8 homolog
Polyclonal Antibody for Human Meiotic recombination protein REC8 homolog
Polyclonal Antibody for Human Meiotic recombination protein REC8 homolog
Polyclonal Antibody for Human Meiotic recombination protein REC8 homolog
Monoclonal Antibody for Human Meiotic recombination protein REC8 homolog
Monoclonal Antibody for Human Meiotic recombination protein REC8 homolog
Monoclonal Antibody for Human Meiotic recombination protein REC8 homolog
Protein for Human Meiotic recombination protein REC8 homolog
Protein for Human Meiotic recombination protein REC8 homolog
Protein for Human Meiotic recombination protein REC8 homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
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Brain .
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Teratocarcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Stomach .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PHE-411
tissue :
Lung .